Weave-UNISONO: launch of a call for proposals with the Slovenian ARIS as the lead agency

Wed, 11/15/2023 - 17:00
Kod CSS i JS

We are pleased to announce that between 14 November 2023 and 12 January 2024, a call for proposals will be open at the Slovenian agency ARIS within the framework of the Weave Programme, with the Slovenian agency acting as the lead agency.

Under the Weave-UNISONO call, if a joint proposal must be submitted to ARIS as the lead agency by 12 January 2024, an NCN proposal must be submitted electronically via the OSF submission system as soon as possible following the submission of the joint proposal to ARIS, by 19 January 2024, 23:59 p.m. at the latest.

PLEASE NOTE: Once the work on the NCN proposal has started in the OSF submission system, the Polish research team has 45 calendar days to complete the proposal and submit it to the NCN. After that, the proposal can no longer be edited, in which case a Polish research team that has not sent its proposal to the NCN must prepare a new proposal and complete it in the OSF submission system.

PLEASE NOTE: NCN proposals processed in the OSF submission system in 2023, with an exchange rate of 1 EUR = 4.7244 PLN, must be completed in and submitted via the OSF submission system by 31 December 2023, 23:59:59. Otherwise, the proposal can no longer be edited, in which case a Polish research team must prepare a new proposal (with an exchange rate of 1 EUR = 4. 5940 PLN) and complete it in the OSF submission system. If a joint proposal has already been submitted to the lead agency, with the budget of the Polish part of the project calculated according to another exchange rate, the NCN proposal will be inconsistent with the joint proposal and may result in the proposal being rejected on the grounds that it does not meet the eligibility criteria.

OPUS 24+LAP/Weave: the latest results

Wed, 11/15/2023 - 14:00
Kod CSS i JS

21 more Polish teams will conduct their research in tandem with German, Slovenian, Austrian and Czech partners under the OPUS 24+LAP/Weave scheme. The NCN has slated a total of more than 33.7 million zlotys in funding for their projects. Meet the latest winners.

Of all calls in the NCN portfolio, OPUS has the broadest formula, targeting researchers at all stages of their academic career. In its 24th round, researchers working at Polish research institutions could win funding not just for domestic research projects, but also wider international ventures based on the Lead Agency Procedure (LAP). Under LAP, they could plan their research in cooperation with teams from Austria, Czech Republic, Slovenia, Germany, Switzerland, Luxembourg or Belgium-Flanders.

As the Lead Agency in the programme, the National Science Centre was responsible for the full merit-based evaluation of all proposals, which then had to be approved by international partner agencies. The Polish teams will be funded by the NCN, while their partners’ funding will come from their respective institutions in Germany, Slovenia, Czech Republic and Austria.

Bi- and trilateral projects

The ranking list features 13 bilateral projects with Germany, 5 bilateral projects with Slovenia, and 3 trilateral projects: Polish-German-Austrian, Polish-Slovenian-Austrian, and Polish-Slovenian-Czech, in different research disciplines: 3 in Arts, Humanities and Social Sciences, 5 in Life Sciences, and 13 in Physical Sciences and Engineering.

In Arts, Humanities and Social Sciences, Dr hab. Anna Horolets from the University of Warsaw has teamed up with Prof. Alexandra Nadine Schwell from the University of Klagenfurt and Prof. Saša Poljak Istenič from the Research Centre of the Slovenian Academy of Sciences and Arts to study the European policy of climate-neutrality for cities and its local interpretations. They will analyse which climate-change issues are seen as especially urgent in several cities that have joined the EU Mission 100 action, which aims to deliver 100 climate-neutral cities by 2030. The researchers will be following the process of transition toward climate neutrality in Warsaw, Klagenfurt and Lubljana. The NCN has awarded more than 1.2 million zlotys to the Polish part of the project.

In the Life Sciences panel, researchers from Poland and Slovenia will work on a project focused on the development of new therapies for inflammatory diseases. Chronic inflammation is involved in the pathogenesis of various disorders, such as arthritis, arterial sclerosis, irritable bowel syndrome, cancer and even depression. Dr hab. Anna Więckowska from the Jagiellonian University Medical College and Prof. Izidor Sosič from the University of Ljubljana will join forces to obtain the first-in-class anti-inflammatory PROTAC molecules that can degrade protein kinases TAK1 and IKKβ. The project was awarded more than 2 million zlotys in funding by the NCN.

Winners in Physical Sciences and Engineering include a Polish-German project to be hosted by the Nicolaus Copernicus Astronomical Center, PAS, headed by Dr. hab. Rodolfo Henrique Smiljanic, in cooperation with Prof. Norbert Christlieb from Heidelberg University.  Entitled “The old Milky Way: a holistic approach for the accurate analysis of metal-poor stars”, this innovative project will try to identify the precise atmospheric parameters of metal-poor stars and their chemical composition. These findings will then help them reconstruct the properties of the first sources of chemical elements of stellar origin in the Universe. The budget of the Polish part of the project is more than 2 million zlotys.

Lead Agency Procedure – LAP

In the latest OPUS 24+LAP/Weave call researchers could request funding for projects conducted without international partners, as well as bilateral or trilateral LAP projects involving foreign cooperation or access to large international research equipment. The call was open to researchers at every stage of their academic career. LAP is a new proposal evaluation standard adopted by European research-funding institutions, designed to facilitate the funding proposal process for international research teams and streamline proposal review.

The domestic part of OPUS 24+LAP/Weave concluded in May. Ranking lists for partner countries under the LAP procedures are being successively published as their funding-agencies approve the results.

Decisions and their delivery

All the positive and negative decisions for OPUS LAP proposals recommended for funding under OPUS LAP in cooperation with German Research Foundation (DFG), Slovenian Research Agency (ARIS), DFG and the Austrian Science Fund (FWF), ARIS and the Czech Science Foundation (GACR) and ARIS and FWF were sent out today. The decisions of the NCN Director are served on the applicant electronically, to the e-mail address indicated in the proposal.

If the applicant is an entity referred to in Article 27 (1)-(7) and (9) of the Act on the National Science Centre, the decision will only be delivered to the Electronic Delivery Inbox (ESP ePUAP) provided in the proposal. If the applicant is a natural person and has listed an ePUAP address in the proposal, the decision will be sent to that address. Otherwise, a message will be sent to the applicant’s indicated e-mail account, containing a link from which the decision of the NCN Director can be downloaded.

The funding decisions of the Director of the National Science Centre are also communicated to the principal investigator and, if the applicant is a natural person, to the host institution indicated in the proposal.

If you do not receive a decision, please make sure that the address (ESP, ePUAP, e-mail) listed in your proposal is correct. If not, contact the person in charge of the proposal, as indicated in the OSF system.

Quantum Technologies Public Policies Report 2023

Wed, 11/15/2023 - 10:14
Kod CSS i JS

Europe is strong-willed to boost European scientific advantage and excellence in Quantum Technologies (QT), and to expand a competitive European industry in QT creating environment where quantum innovation can thrive attracting investments in this field. National policies act as the foundation upon which Europe's quantum future is built. They provide the necessary framework for countries to invest strategically, collaborate effectively, and contribute to the European leadership in QT.

The QuantERA research funding programme, which brings together the scientific community, funding agencies, and industry representatives to leverage transnational cooperation in QT, continuously monitors the evolving landscape of national quantum programmes and approaches.  

In 2023 QuantERA mapped and illustrated developments in QT programming in the second edition of the report Quantum Technologies Public Policies in Europe. The publication delivers a snapshot of the European policies, as well as funding instruments provided by relevant Research Funding Organisations. It gives a comprehensive view of the current quantum landscape, offering valuable data and analysis, which can serve as a reference and toolkit for policymakers to shape the future development of QT at national and the European level.

The report is the result of the joint efforts of the QuantERA Consortium partners, supported by the EC and the QT Flagship. It summarizes the findings from an inventory conducted among 31 European Union member states and associated countries. In addition to an overview of national and regional policies for QT, the publication includes information on new developments with regard to the previous publication –  Quantum Technologies Public Policies in Europe, 2020.

While providing an overview of the current state of QT in Europe, QuantERA’s report points also the readers to the horizons of the field’s landscape enabling them to look beyond and identify the next steps forward to increase European potential in QT.

Results of the international call on urban issues and challenges

Tue, 11/14/2023 - 12:00
Kod CSS i JS

The JPI Urban Europe Network has concluded its BTC ENUTC Call 2023. The winners include two international research projects involving researchers from Poland. PLN 1.3 million will be awarded for research. 

The JPI Urban Europe supports researchers pursuing international interdisciplinary research projects responding to the challenges of cities and urban areas. The call launched this year (Building transformation capacity through arts and design: Unlocking the full potential for urban transitions) was focused on urban development and development of urban areas. 

The BTC ENUTC call was open to researchers working in the Polish research institutions and intending to pursue international research projects in partnership with researchers from Belgium. Bulgaria, Latvia, the Netherlands, Romania or Sweden.

The winning applicants included five international research projects, two of which involved researchers from Poland. They will be awarded over PLN 1.3 million.

  • unLoc – Exploring the synergy of human and machine creativity in architecture. Redesigning urban space through machine learning, artistic expression, and community collaboration.

    Jacek Złoczowski from the Pedagogical University of Krakow is the principal investigator of the Polish research team. The project budget is over PLN 900,000.

    The project aims to develop a method of redesigning cities and buildings with a difficult history by using post-communist architecture as an exemplary manifestation and redefining their form and meaning. Researchers will recommend new functions and strategies of transformations of buildings to adjust them to the needs of their residents. In the project, they will use the machine learning algorithms that will help them create alternative pictures of urban areas. 

  • The Urban Food Factory (Miejska Fabryka Żywności) – A web-based decision support manual to reuse inner-city multi-storey carparks for controlled environment agriculture.

    Monika Anna Szopińska-Mularz from the z Rzeszów University of Technology is the principal investigator of the Polish research team. The project will be awarded funding of nearly PLN 415,000.

    The project aims to demonstrate how adaptive reuse of car parking structures for controlled environment agriculture can strengthen urban social, economic and environmental resilience. A web-based decision support manual will be developed for the creation of Urban Farming Living Labs. Interactive 3D models will be created to improve understanding of the concept.

NCN within the JPI Urban Europe network

The National Science Centre has cooperated with the JPI Urban Europe Network since 2015 in the organisation of calls for proposals aimed at researchers pursuing international research projects in the area of urban issues and challenges. So far, Polish researches have had an opportunity to apply for funding in seven calls of JPI Urban Europe.

Extracellular vimentin: a significant factor of brain damage in COVID-19

Principal Investigator :
Łukasz Suprewicz
Medical University of Bialystok

Panel: NZ6

Funding scheme : PRELUDIUM 21
announced on 28 march 2022

The SARS-CoV-2 virus, responsible for the outbreak of the COVID-19 pandemic in 2020, has had a huge impact on worldwide healthcare systems. Although it was initially seen as a factor of respiratory infection, it soon turned out it may also lead to severe damage to the central nervous system (CNS). Up to 40% of patients experience chronic neurological symptoms, commonly referred to as "Covid brain fog”. Although some of these (e.g., dizziness) are relatively mild, some patients develop serious sequelae, such as stroke or encephalopathy (brain damage). In light of the ongoing SARS-CoV-2 pandemic, it is crucial to understand the mechanism behind this damage and develop effective treatments.

How SARS-CoV-2 affects the brain remains a subject of intensive research. One hypothesis points to the excessive secretion of inflammatory mediators, known as the “cytokine storm” and the direct action of protein S, which the virus uses to enter host cells. These processes are indicated as some of the factors that damage the barrier between the blood and the structures of the brain (the so-called blood-brain barrier), allowing harmful substances, such as viruses and inflammatory proteins, to pass through in increased quantities.

It is in this context that vimentin makes an appearance. Vimentin is a protein that builds the cytoskeleton of most cells, where it plays a key role in fundamental processes, such as cell division, migration and the protection of the cell nucleus from mechanical damage. When released into the bloodstream by immune cells in response to inflammation, it is known as extracellular vimentin. There are two forms of extracellular vimentin: that which is bound or unbound to the cell surface. In an earlier project, we showed that extracellular vimentin acts as a co-receptor for SARS-CoV-2, which means it is necessary for a cell to be effectively infected (Suprewicz et. al. Small 2022).

Łukasz Suprewicz, photo by Michał ŁepeckiŁukasz Suprewicz, photo by Michał Łepecki The purpose of this project is to focus on the role of extracellular vimentin in CNS inflammation associated with a SARS-CoV-2 infection. We investigate the impact of extracellular vimentin on different cell types present in the brain, such as endothelial cells and astrocytes, using a 3D blood-brain barrier flow model to assess the permeability and integrity of endothelial cells, and the adhesion and migration of immune-response cells in the presence of vimentin and the SARS-CoV-2 protein. In the next stage, we will evaluate the impact of the substances in question on inflammation by analysing the secretion of inflammatory mediators. The study will culminate in a molecular-level assessment of the signaling pathways characteristic of SARS-CoV-2 infections and inflammatory blood vessel damage.

The project may significantly increase our knowledge of the effects of extracellular vimentin and its modified forms on endothelial and immune cell responses in a SARS-CoV-2 infection. This, in turn, may contribute to developing more effective treatments for COVID-19 patients, especially those with neurological complications. The project may also identify new therapeutic targets to help fight potential future global pandemics, considering that the role of extracellular vimentin as a co-receptor is not restricted to SARS-CoV-2 but also applies to other infections, including those caused by bacteria.

Diapedesis of human neutrophils, untreated or stimulated by vimentin (Vim), citrullinated vimentin (CitVim), or lipopolysaccharide (LPS) in a 3D model of blood vessels. Neutrophil elastase (green), actin (red), DNA (blue).

Diapedesis of human neutrophils, untreated or stimulated by vimentin (Vim), citrullinated vimentin (CitVim), or lipopolysaccharide (LPS) in a 3D model of blood vessels. Neutrophil elastase (green), actin (red), DNA (blue)..

Project title: Extracellular vimentin as a signaling molecule in the pathogenesis of inflammation and central nervous system damage in patients with COVID-19

Łukasz Suprewicz

Kierownik - dodatkowe informacje

Graduate of the Medical University of Białystok and laboratory diagnostician. PhD student (4th year) at the Doctoral School of the Medical University of Białystok. Author and co-author of over twenty publications in international press/ journals. His research focuses on the molecular mechanisms of interaction between proteins, pathogens and immune-response cells. PI in a PRELUDIUM 21 project and member of a PRELUDIUM BIS1 team, headed by Prof. Dr hab. Robert Bucki.

Łukasz Suprewicz, photo by Michał Łepecki

MINIATURA 7 results are in

Mon, 11/13/2023 - 15:22
Kod CSS i JS

The MINIATURA 7 call for research activities was open to researchers employed at the Polish research institutions who were conferred their PhD degree after 1 January 2011. The NCN funding will allow the early-stage researchers to get their first grant implementation experience and to prepare the basis for research projects that will be later submitted to the NCN calls or other national or international calls for proposals. 

Sixth ranking list 

Research activities under MINIATURA 7 can be carried out in the form of preliminary/pilot studies, library and archive searches, fellowships, research visits and/ or consultations. The winners of the sixth and final round of the call address a variety of research subjects important and relevant for the societies and the environment of the 21st century. The subjects include human existence in virtual reality, optimisation of disease therapy or innovative methods of counteracting the negative impact of civilisation development and human activity in nature.

The largest group of winners on the ranking list represents Life Sciences. They will carry our 98 research activities worth a total of over PLN 4.5 million, including activities oriented towards improving or seeking new therapies for human diseases, including cancer. Paweł Hikisz from the University of Lodz will carry out a preliminary/pilot study as part of the activity entitled “Pyrazoline derivatives condensed with chromanone or flavanone in colorectal cancer therapy: analysis of molecular anticancer activities”. Joanna Bogusławska from the Medical Centre of Postgraduate Education will address the impact of probiotic strain L. lactis on gene expression in keratinocytes, looking for therapeutic potential in the treatment of psoriasis.

82 researchers selected in Physical Sciences and Engineering will tackle, inter alia, the problems of natural or man-made disasters disasters. One of the funded activities is a fellowship of Piotr Kopka from the National Centre for Nuclear Research who will travel to Japan where he will be involved in the reconstruction of the source term from the Fukushima Daiichi Nuclear Accident using the JRODOS system and measurement data at the Fukushima University. Emilia Karamuz will research the application of novel measurement methods to improve the description and modelling of drought at the Institute of Geophysics, Polish Academy of Sciences. Nearly PLN 3.2 million will be spent on research activities in the field of Physical Sciences and Engineering. 

In Arts, Humanities and Social Sciences, the MINIATURA grants will go to 58 researchers, including Marcin Rządeczka from the Maria Curie-Skłodowska University in Lublin who will go on a research visit to analyse the therapeutic chatbots bias in artificial intelligence mental health technology algorithmic fairness bias mitigation strategies. Dagmara Gałajda from the University of Silesia in Katowice will carry out a preliminary/pilot study on Generation Z, group dynamics, communicative competence, willingness to communicate, digital body language, well-being, Danish higher education, and Polish higher education. Over PLN 1.6 million will be spent on research activities in the field of Arts, Humanities and Social Sciences.

The sixth ranking list – funding per panel

  • Arts, Humanities and Social Sciences: 58 research activities, PLN 1,642,014  
  • Physical Sciences and Engineering: 82 activities, PLN 3,193,840
  • Life Sciences: 98 activities, PLN 4,563,147

The total value of research activities on the MINIATURA 7 ranking list is exactly PLN 9,399,001.

About MINIATURA 7

The main objective of the call is to finance research activities carried out in preparation for future research projects that will be submitted to NCN calls for proposals, as well as other domestic and international calls. Researchers can apply for funding from PLN 5,000 to PLN 50,000 for a research activity planned over a period of up to 12 months.

Funds for research activities carried out under the MINIATURA 7 call were divided proportionally between the months during which proposals were accepted. In this edition, the submission deadline was 31 July 2023.

MINIATURA was first announced in 2016. The original idea was to increase the numbers of NCN programme winners, encourage applicants from smaller academic centres and reduce interregional inequalities. A total of over 3.8 thousand research activities have been funded by the NCN in the previous six rounds of the call.

MINIATURA 7 funding was awarded to 621 proposals: 243 in Life Sciences, 205 in Physical Sciences and Engineering and 173 in Arts, Humanities and Social Sciences.

The success rate was over 34.7%.

The winning applicants include researchers at the onset of their research career: 424 with a PhD degree and 166 researchers with a degree in engineering.

More proposals were submitted by women than men and the majority of winners are female researchers. Funding was awarded to 374 female researchers and 247 male researchers.

74.5% of proposals involve preliminary/pilot studies. 

Nearly 83% of all grants will go to universities, with the Jagiellonian University and the University of Lodz leading the fray.

Research activities will be carried out by 85 universities, research institutes of PAS and the Łukasiewicz Centre as well as other institutes. The largest number of projects will be hosted by the Jagiellonian University and the University of Lodz. The top ten institutions with the largest number of research activities to be funded also include the Gdańsk University of Technology, Wrocław University of Science and Technology, Adam Mickiewicz University in Poznań, Warsaw University of Life Sciences, University of Warsaw, Poznań University of Medical Sciences, University of Silesia in Katowice and University of Wrocław.  

A total of over PLN 24 million was handed out within the framework of MINIATURA 7.

MINIATURA 7 call annauncement

MINIATURA 7 results

Funding decisions are sent to the ESP ePUAP address indicated in the proposal. If you have not received a decision, please make sure that the address listed in the proposal is correct. If not, contact the person in charge of handling the proposal, as indicated in the OSF system.

New approaches in determining the impacts of chemical pollution to protect the biodiversity of the Baltic Sea

Principal Investigator :
Prof. dr hab. Ksenia Pazdro
Institute of Oceanology Polish Academy of Sciences

Panel: NZ8

Funding scheme : BiodivProtect
announced on 1 October 2021

Marine ecosystems today are facing many problems, such as anthropogenic threats, climate change and other factors that negatively affect their health and function. This is also true of the Baltic Sea. The peculiar geographical and hydrological features of the Baltic make it particularly vulnerable to different anthropogenic pressures.

Prof. Ksenia Pazdro, photo by Michał ŁepeckiProf. Ksenia Pazdro, photo by Michał Łepecki The Baltic Sea is a semi-enclosed basin with brackish waters and relatively low biodiversity. It is located in a densely populated region, with intensive agricultural and industrial activity underway within its catchment area. In addition, its waters account for c. 15% of global marine transport. As a result, chemical pollution is a major threat, which negatively affects the health of Baltic fauna and flora and, by corollary, its overall biodiversity. National, regional and EU remediation measures thus far have improved the situation; the amount of hazardous substances discharged into the sea has been reduced. However, they continue to be present in the ecosystem, and extreme weather phenomena, such as sea storms, increase the risk of their reintroduction into the Baltic. Attention should also be drawn to a new group of compounds, known as micropollutants (such as pharmaceuticals, plasticizers, detergents, personal protection agents). Micropollutants are eliminated during wastewater treatment to varying degrees, but little is known about their impact on living organisms. Keeping a large ecosystem like the Baltic Sea in good health thus requires further, decisive measures by institutions responsible for marine ecosystem protection. To this end, however, they need modern, reliable and useful tools. Monitoring activities thus far have focused on two lines of investigation: the chemical composition of the environment and the assessment of the health of marine organisms. However, to date, research has only considered the impact of selected, individual substances, rather than the entire “cocktail” of chemical elements and compounds present in the Baltic.

Prof. Ksenia Pazdro, photo by Michał ŁepeckiProf. Ksenia Pazdro, photo by Michał Łepecki The Detect2Protect project proposes a change of paradigm in Baltic protection and a shift toward a more holistic approach focused on biological effect-based methods (EBM). There is increasing evidence that effect-based methods may help distinguish chemical toxicity from other possible causes of biodiversity loss and serve as an early warning sign of potential threats. The goal of the project is to improve our understanding of the cause-and-effect relationships between environmental pollution and changes in biodiversity and develop a tool for environmental risk assessment in different Baltic regions. To this end, we will use specific biomarkers, i.e. biochemical indicators of the impact of pollutants on marine organisms. The project involves harmonised research by teams from marine research institutions in Finland, Estonia, Latvia, Lithuania, Sweden, Poland and Italy, with the aim of tracking relationships between chemical pollution in the Baltic and potential biodiversity loss, based on existing chemical pollution monitoring and biological data. We will also carry out joint fieldwork in the coastal regions of Poland, Latvia, Lithuania, Estonia, Sweden and Finland to compare polluted sites with reference sites. Our project will involve measurements of chemical pollutant concentrations in various elements of the environment and their biological effects in representative species of molluscs, crustaceans, polychaeta and fish in each region. Biodiversity will be assessed through eDNA metabarcoding. In order to develop appropriate predictive modelling tools, we will also need a thorough analysis and integration of collected data.

We hope our findings will help define the relationship between water pollution in the Baltic Sea and the biochemical reaction of its organisms, as well as to identify indicator species and biomarkers for different marine regions which, it is hoped, will facilitate biodiversity protection. Our findings, including a field-tested set of biological indicators (as an early warning tool) and recommendations for use in different areas of the Baltic Sea, will be presented to interested institutions, such as HELCOM. We will also share what we have learned with the general public, so as to raise public awareness of the impact of chemical mixtures on potential biodiversity loss in the Baltic Sea.

Project title: Detect2Protect: New approaches in determining the impacts of chemical pollution to protect the biodiversity of the Baltic Sea

Prof. dr hab. Ksenia Pazdro

Kierownik - dodatkowe informacje

A marine chemist, she graduated in oceanography from the University of Gdańsk. Since the early days of her career, she has been affiliated with the Department of Marine Chemistry and Biochemistry of the Institute of Oceanology of the Polish Academy of Sciences in Sopot. In 2021, she earned the title of professor ofexact and natural sciences. Her research interests centre on the circulation of persistent organic pollutants and emerging pollutants (e.g. pharmaceuticals) in marine ecosystems (the Baltic Sea and the Svalbard fjords) and assessing their impact on marine organisms. She is an author of several publications in international journals and has participated in the work of the Polish Scientific Committee on Oceanic Research, PAS for many years.

Prof. Ksenia Pazdro, photo by Michał Łepecki

Impact of the rotating magnetic field on drug efficacy against bacterial biofilms

Principal Investigator :
Prof. Dr hab. Karol Fijałkowski
West Pomeranian University of Technology in Szczecin (ZUT)

Panel: NZ6

Funding scheme : OPUS 14
announced on 15 September 2019

Bacterial infections caused by organised microbial communities, known as biofilms, have been a growing, complex and multidisciplinary medical issue. Such structures are covered by a protective extracellular matrix, which makes it significantly more difficult for antibiotics and antiseptics to reach bacterial cells that are hidden inside it. This is one reason why biofilms exhibit up to 1000 more resistance to antimicrobial agents than cells of the same microorganism in free-swimming (a.k.a. planktonic) form (without the protective matrix layer). Despite significant progress in science and technology, there are still no sufficiently effective methods of preventing and combating infections caused by biofilms.

Prof. Karol Fijałkowski, photo by Michał ŁepeckiProf. Karol Fijałkowski, photo by Michał Łepecki In our earlier research, we discovered that a Rotating Magnetic Field (RMF) of specific parameters increased the antimicrobial activity of antibiotics and antiseptics against pathogenic biofilms. We realised this discovery might be of fundamental importance for the development of innovative methods of preventing and combating biofilms, but for this to happen, we needed to elucidate the mechanisms behind the effects we had observed. Accordingly, the primary goal of this project was to explain the mechanisms of this increased activity of antimicrobial compounds, antiseptics and antibiotics, against bacterial biofilms in the presence of RMF.

Research was performed with the aid of RMF generators constructed within the framework of a previous project, “Lider V”, funded by the National Centre for Research and Development.

Using advanced spectrometry techniques, we showed that the RMF changed the chemical composition of the biofilm matrix, i.e., causing it to become more porous, as seen with electron microscopy. We also observed changes in protein concentrations in the cell walls of bacteria exposed to the RMF, and showed differences in their metabolism manifesting, for instance, in changed concentrations of information-transmitting molecules. We proved that the effect of the RMF (in the absence of any antimicrobial compound) was manifested on a spectrum of relatively subtle changes that accumulated primarily in external cellular structures, cell walls and membranes, and the biofilm matrix. The activity of the RMF was so subtle that the cells were able to eliminate damage relatively quickly, which meant there was no lasting post-exposure effect. However, once an antibacterial agent was introduced into bacterial cultures exposed to the RMF, especially an agent designed to alter cell wall structures, its efficacy was significantly increased, as evidenced by a rise in the number of dead cells. This RMF-induced increase in the efficacy of the antimicrobial agent was also observed at lower concentrations and with shorter contact time, as opposed to the effects achieved in a set-up that had not been exposed to the RMF. We determined that the increase in efficacy was due to a number of changes induced by the RMF in the morphology of bacteria, as well as their metabolomic and proteomic processes, which meant that the antimicrobial agent acted against functionally- and structurally-weakened cells and, in the case of biofilms, also a partially degraded matrix.

The project was carried out in a consortium with the Łukasiewicz Research Network – PORT Polish Centre for Technology Development. The PI on the partner side was Dr hab. Adam Junka, Professor at the Medical University Wroclaw.

Project title: Analysis of mechanisms of increased efectivness of antimicrobial substances against biofilms in the presence of a rotating magnetic field

Prof. Dr hab. Karol Fijałkowski

Kierownik - dodatkowe informacje

Microbiologist, academic teacher, professor of Physical and Life Sciences, specialised in biology and biotechnology. Head of the Department of Microbiology and Biotechnology at the ZUT Centre for Nanotechnology Research and Education in Szczecin. Together with his team, he has conducted interdisciplinary research into the impact of magnetic fields on microbes. His current research interests are focused on using magnetic fields to increase the efficacy of antimicrobial agents against pathogenic bacteria.

prof. dr hab. Karol Fijałkowski

Online lectures by winners of 2023 NCN Award

Wed, 11/08/2023 - 13:00
Kod CSS i JS

Karolina Ćwiek-Rogalska, Łukasz Opaliński and Katharina Boguslawski will deliver lectures in the “Science at the Centre” series launched by the Copernicus Centre and the National Science Centre. The first meeting will be held on 14 November.

The first “Science at the Centre” lectures were delivered by the 2020 NCN Award winners. Together with the Copernicus Centre for Interdisciplinary Studies, we have already hosted nine meetings which had over 246 thousand viewings.  

The first lecture this year will be delivered by Karolina Ćwiek-Rogalska, 2023 NCN Award winner in Arts, Humanities and Social Sciences. She specialises in cultural studies, Czech studies and ethnology at the Institute of Slavic Studies, Polish Academy of Sciences. Her lecture is entitled: “Things acting as “ghosts”. Displacements and emergence of new cultures in Central Europe”.

This is how she announces her talk: 

“We often think about ghosts as the spirits of the dead haunting the living. But what if we understood them as material remains, bringing to light overlooked past and enabling us to grasp the experience of the otherness? I propose such an approach in research on the effects of displacement associated with the end of WWII when territories previously inhabited by German and German-speaking communities were forced to migrate from today’s Poland, Czechia and Slovakia, and replaced by new inhabitants. What was the settlers’ experiences with things and spaces the previous inhabitants had left behind? How was it remembered and how does it live on in the memory of the next generations? I will answer these questions using the research tools of cultural anthropology (in particular, participant observations and field interviews) and archive material analysis, and will discuss the new cultures of Poland’s “Recovered Territories” and Czech "pohraničí.”

The lecture will be streamed online on the YouTube Channel of the Copernicus Center, on 14 November at 6 p.m. and will be followed by a discussion. Participants are welcome to ask questions.

The next lecture will be delivered on 28 November by Prof. Łukasz Opaliński, 2023 NCN Award winner in Life Sciences and the last lecture will be given by Prof. Katharina Boguslawski, 2023 NCN Award winner in Physical Sciences and Engineering.

More information:

NCN Award ceremony

NCN podcast on NCN Award, featuring K. Ćwiek-Rogalskiej and Prof. Joanna Golińska-Pilarek, NCN Council member.

Heterogeneous diamond biosensing nanoarchitectures

Principal Investigator :
Dr hab. inż. Robert Bogdanowicz
Gdańsk University of Technology

Panel: ST7

Funding scheme : OPUS 22
announced on 15 September 2021

Our project represents an important innovation in the field of carbon nanomaterials. Nanostructures are geometric, complex, often periodic surfaces of nanometric size, i.e., approximately 1/100 thinner than a human hair. Our project focuses on developing periodic diamond nanostructures with extraordinary optical and electronic properties, which are difficult or impossible to achieve using conventional technologies. Importantly, we use synthetic diamond for that purpose, which means we can obtain materials characterised by exceptional chemical stability and biocompatibility.

Diamond is well known for its incredible hardness, which means it is very difficult to nanostructurise, i.e., have its surface shaped in nanoscale with the use of atoms. However, thanks to advanced technologies used in the semiconductor industry, we are able to deposit synthetic diamond in form-defined matrices to create three-dimensional nanostructures. Another approach is to fabricate three‐dimensional nanostructures from diamond composites that induce periodicity.

dr hab. inż. Robert Bogdanowicz, fot. Michał Łepeckidr hab. inż. Robert Bogdanowicz, fot. Michał Łepecki The aim of our project is to develop and study new three-dimensional diamond nanostructures, optimised for applications in medicine and biosensor production. What makes our structures unique is the possibility of obtaining simultaneous optical and electrochemical signals, which reduces the risk of error and shortens measurement time as compared to traditional sensors. Taken together, optical and electrochemical data are very reliable and useful for early diagnostics. This advance allows us to detect specific biological targets, such as viruses, cancer cells, bacteria and disease markers in a highly selective and sensitive manner. Biosensors are detection platforms that use biological receptors, such as antibodies, to detect different biological targets. In order to achieve adequate selectivity for a given biological target, the sensors need to be bio‐functionalised; their surface must be sensitised to specific biological interactions with specific proteins, which are antigen proteins in our case.

The project crucially involves international cooperation between Polish and Czech researchers. Researchers based in Prague specialise in developing and diagnosing periodic diamond structures; researchers in Gdańsk focus on modifying their electrochemical parameters; and our Warsaw team has expertise in optoelectronics, mainly dealing with biosensors. This synergy of expertise and experience will help us understand and develop the potential of these fascinating nanostructures.

Project title: Heterogenous diamond biosensing nanoarchitectures: opto-electro-chemical interactions with antibody complexes

Dr hab. inż. Robert Bogdanowicz

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Bogdanowicz earned a PhD in electronics (summa cum laude) from the Gdańsk University of Technology in 2009, and went on to devote the next few years of his career to researching and developing innovative technologies. In 2010-2011, he worked as a post-doc in Germany and, upon his return to Poland, took leadership of a research team at the Department of Metrology and Optoelectronics of the Gdańsk University of Technology. His research focuses on the development of CVD (Chemical Vapor Deposition) diamonds and their applications in biomedical, environmental and biochemical sensors. In 2015, he was a Fulbright Senior Scholar Award Program fellow at the California Institute of Technology (Caltech), where he joined a team led by Professor William Goddard (Materials and Process Simulation Center), working on hybrid 3D diamond structures. He is the author of more than 200 articles, book chapters, conference materials and special issues of scientific journals such as “Diamond and Related Materials”, as well as the owner of 8 patents. His innovative diamond-based sensor technology is already being developed by industry.

Dr hab. inż. Robert Bogdanowicz